Research Interests

by arblelab

The Arble lab is broadly interested in the neuronal intersection between sleep/circadian biology and obesity/diabetes. How the brain controls behavior and disease states is an exciting and growing field with many opportunities to advance our basic understanding as well as develop novel treatment strategies. The Arble lab uses preclinical models to uncover candidate brain regions involved in sleep/circadian biology and obesity/diabetes and utilizes that information to explore novel treatment strategies.

More specifically, the Arble lab has an interest in:

  • How does environmental light and/or circadian biology affect breathing behavior?
  • How do high-fat diets change our brain and, in turn, change the way we breathe?

Current Funding:

  • Fulbright U.S. Scholar Award — Environmental Light and Obesity Risk: Insights from Southern European Populations. PI; $12,676; 4 months
  • Way Klingler Sabbatical Fellowship, Marquette University. PI; 1 year
  • NSF CAREER — Determining how light modulates respiratory behavior to inform an increasingly light-polluted world. PI; $1,250,000 ($855,610 direct); 5 years.
  • NIH R01 — Mechanisms and therapeutic potential of phrenic proprioceptors after spinal cord injury. CoInvestigator; Kristi Streeter, PI; $2,913,080 total ($33,735 direct to Arble); 5 years.
  • NIH-NHLBI R15 — Cultivating novel treatments for obesity-related respiratory disease by uncovering neuronaletiology. PI; $456,882 ($298,616 direct); 3 years.

Dr. Arble has been previously funded by:

  • Craig H. Neilsen Foundation — Phrenic afferent-induced recovery of respiratory motor output following spinal cord injury. Co-Investigator; Kristi Streeter, PI; $400,000; 2 year
  • Marquette University, Mellon Grant (PI, Arble) “Creative Problem Solving: a new course designed to promote STEM education and discovery”
  • American Heart Association, Innovative Project Award 20IPA35320195 (PI, Arble) “Targeting the brain as an effective treatment for sleep apnea.”
  • American Heart Association, Scientific Development Grant 17SDG33660108 (PI, Arble) “The role of neuronal leptin in the pathogenesis, and treatment, of sleep apnea and cardiometabolic disease”
  • NIH/NIDDK F32 DK097867 (PI, Arble) “Circadian disruption and bariatric surgery: impact on metabolism, clock biology”
  • NIH/NIA F31 AG035621 (PI, Arble) “Aging and meal timing interact to exaggerate weight gain”