The Arble lab is broadly interested in the neuronal intersection between sleep/circadian biology and obesity/diabetes. How the brain controls behavior and disease states is an exciting and growing field with many opportunities to advance our basic understanding as well as develop novel treatment strategies. The Arble lab uses preclinical models to uncover candidate brain regions involved in sleep/circadian biology and obesity/diabetes and utilizes that information to explore novel treatment strategies.
More specifically, the Arble lab has an interest in:
- Neuronal mechanisms underlying sleep apnea and obesity-associated disordered breathing
- Neuroendocrinology underlying circadian rhythmicity and disruption and the effects on body weight and glucose regulation
The Arble lab currently receives start-up funds from Marquette University and the American Heart Association (17SDG33660108 PI, Arble) for the project entitled, “The role of neuronal leptin in the pathogenesis, and treatment, of sleep apnea and cardiometabolic disease.”
Dr. Arble has been previously funded by:
- NIH/NIDDK F32 DK097867 (PI, Arble) “Circadian disruption and bariatric surgery: impact on metabolism, clock biology” 09/2012 – 09/2014
- NIH/NIA F31 AG035621 (PI, Arble) “Aging and meal timing interact to exaggerate weight gain” 07/2010 – 07/2011